A THOUGHT PROVOKING RESEARCH
The subject of parasitic research is the most complex topic that we have been
involved so far. For reasons yet to be determined, parasites have been a very antagonistic subject.
The following will provide an overview of the research findings:
While engaged in EPM research, investigators RamaSharma Kristapati, Ph.D., of Endocrine
Technologies, Inc and Thelma Dunnebacke, Ph.D., a friend and associate, observed worms in the blood samples being
processed. The worms were subsequently identified as strongyle type
parasites. As a result of these findings, all of the EPM research blood samples were examined for
parasites. The findings showed parasitic infections at an alarming level.
A comparison of these findings showed a pattern that required further investigation. A large number
of horses showing EPM
like symptoms tested low or negative for S. Neurona
and/or Neospora infections; however, upon
examination, strongyle type parasites were present
in the blood samples. The investigation into the link between EPM negative
equine and neurologically deficit equine with vascular parasite infections
continued. At the onset of the investigation collection and cataloging of samples
was limited to rescued equine from Indiana. The test results from those blood samples revealed a high
level in most subjects. It was determined that this was not an adequate
sampling of the general equine population, so the research was expanded to include a variety of equine from a larger geographical area.
In the beginning the blood collections were limited to Indiana equine of all ages, breeds and all ranges of facilities. The
results of the analysis of the blood samples collected were comparable to the
initial findings. Parasitemia was found even in a wide
variety of the most well kept, well maintained equine in Indiana.
The research area was increased to include Arizona, Arkansas, Kentucky, Ohio and Texas. Working with a select number of veterinarians, Marcia Dubois, DVM
(Texas), Luann Groves, DVM (Texas), Jerry Singleton, DVM (Arkansas), Barbara Truex,
DVM (Arizona & Oklahoma), and Madalyn Ward, DVM (Texas), hundreds of blood
samples were successfully collected and analyzed. The analysis supported the
earlier findings. Parasitemia was diagnosed successfully by the
veterinarians, based on an analysis of the blood samples. The horses were
treated by the veterinarians and success stories started mounting. Not only
EPM like symptoms, but a wide variety of disorders and diseases, were resolved after treatment
for the parasitemia. The most devastating adverse health
conditions were noted in long term, low level parasitemia. Different degrees of recovery
were noted from the following diseases, disorders, and/or
conditions: Allergies, Amyotrophy, Anemia, assorted Joint Disorders, Colic, Dermal Lesions,
Dermatitis, Edema, Gastritis, Heaves, Inferior Performance, Laminitis, Lethargy,
General Lameness, Muscle Wasting, Neurological Deficit, Pleurisy and Chronic Respiratory Infections.
In addition to equine at the research facility there are canines with medical
disorders. A select group from our research staff, comprised of pre-veterinarian, veterinary
technician and university
biology students, began to analyze the canine blood samples with the same
protocol used in the equine research. The results were
remarkably similar to the equine findings, vascular strongyle type parasitic infection.
Upon successful treatment of the test subjects, different levels of
recovery were noted from the following diseases, disorders and/or
conditions: Allergies, Anemia, Assorted Joint Disorders, Dermal Lesions, Dermatitis,
Gastritis, Lethargy, and Seizures.
As the research continued there was exposure to more equine with
parasitemia on a regular basis. An individual case stands out for the
following reasons: The equine had
been treated with the current accepted protocols for respiratory infections,
including the use of steroids. It was determined from a continual analysis
of the subject’s blood, that the addition of steroids to the therapy increased
both the population and health of the parasites. When the owner of the
equine subject observed the symptoms displayed, he saw a similarity in the
symptoms he personally had been experiencing. The
possibility of an equine to human link was suspected. The owner requested
an analysis of a secretion from a lesion on the left side of his abdomen.
An analysis was conducted and strongyle type parasites were observed.
The facility began to further explore the human infection rate with startling
results. Two medical doctors were enlisted to aid in the research and to properly assess
infection levels to the equine blood samples were found. In further testing of the infection rate with regards to humans,
members of our research
staff ventured out to the public. They collected swabbed specimens from a random
selection of public restroom facilities. The findings were
similar to the blood samplings in that there was a presence of strongyle type
In equine, urine has provided reasonably accurate pre
screening of certain types of parasitic infection, although not definitive. Little weight was given to these findings
except in the area of frequency, and ease of
detection among the general human population.
The human subjects with positive hematological exams were introduced to these
observations and chose to obtain
treatment. Further observations of those subjects revealed different degrees of recovery from the
following diseases, disorders, and/or conditions:
Dermal Lesions, Dermatitis, Edema, Fibrosis, Gastritis, High Blood
Pressure, Lethargy, Ovarian cysts, Pleurisy, and Sinusitis.
One consistent finding in all of the research, human, canine or equine, was
that white blood cell counts that are commonly used to diagnose vascular
parasitic infections are not reliable in diagnosing the presence of this family
of parasites. In one case it was documented that parasites were observed
in a blood sample; the subject went to his medical doctor,
advised him of the discovery, whereupon the doctor conducted his own blood
and sent it to a lab for evaluation. The
results of the lab analysis with whatever tests that were run, showed no parasitic infection, however the photographic
evidence was conclusive and treatment was started. In human, canine
and equine, commonly used fecal samples to measure parasitic infections
are equally unreliable in determining vascular parasitic infections. The
current accepted practice of analyzing fecal samples for the detection of all
parasites is rarely valuable. A positive fecal analysis may support a conclusion
of gastrointestinal parasites, but does not support the presence of
parasitemia; just as a negative fecal analysis does not rule out parasitemia. Noted in
the research are multiple cases of clear fecal analysis, with accompanying
photos of vascular parasites.
Collection of blood samples has been ongoing for three years. Thousands
of photographs supporting our observations have been cataloged.
Aboriginal Resource and Development Services, Inc has some of the best
research supporting the findings. (Click on their link
to read more!)
The following is quoted from their publication:
"This disease can be diagnosed and cured, but because its symptoms mimic those of other diseases, strongyloidiasis is mostly not
recognized. A person with Strongyloides whose immunity is impaired is in danger of dying. Under those circumstances, the worms multiply rapidly, invade any part of the body and overwhelm the patient. Secondary bacterial infection increases the intensity of the illness. If such patients are not promptly diagnosed and given the specific treatment for Strongyloides, they die.
Chronic Strongyloidiasis typically lasts for decades before being diagnosed and treated. In some cases, it is carried to the grave undiagnosed after years of ill health, or it may develop into severe illness (which may still be undiagnosed) and cause death.
60% of deaths due to Strongyloidiasis are caused by the administration of corticosteroid drugs to patients with chronic Strongyloidiasis. Guidelines for the use of these drugs currently do not include any warning to doctors about Strongyloidiasis. Other conditions which depress the immune system also lead to Severe Strongyloidiasis and death if not successfully treated. These conditions include malnutrition, lymphoma, HTLV-1 and advanced AIDS. The duration of the final illness varies from 1 to 90 days."
findings with regards to humans were consistent with ARD publications in all areas but one. The
infection and/or re-infection source was animal and environmental, not a failure of sanitary
The best example
of the resilience of this strain of parasite was noted when a manure sample was
collected from a manure collection area at an equine facility near Tucson,
Arizona. The sample had been exposed to ambient temperatures in excess of 80
degrees, with limited humidity for 48+ hours, no temperatures were recorded from
inside the manure pile. The equine at the facility
were on a regular deworming program with Ivermectin rotations. The sample
was collected in a new latex glove, sealed, placed in a box and shipped to
Indiana. The sample was received for processing in the lab 7 days after collection. The sample was then prepared and
cultured on day 8. The culture was examined, and parasites consistent with
those observed in fresh blood samples, were documented.
Following the accepted protocols for deworming, our research
staff was rarely able to obtain parasite free blood samples. Our research findings suggest an acquired resistance exists to the current
deworming protocols. Further testing included increased dosages of various
types and brands of oral
dewormers, the dosage began
with the normal dosage instructions. When that
failed, the dosage was increased slowly in an attempt to obtain parasite free
blood samples. This technique was only successful in approximately 30% of
the cases and vascular re-infection was noted in some test subjects even when a daily
dewormer was administered. This is a very dangerous technique and not
recommended. All equine were under close medical observation.
Newly developed products were used successfully
to achieve parasite negative blood results. These products will be released
when Endocrine Technologies, Inc. markets the products.
No dewormer testing was performed on vascular parasite positive
canine subjects, as they were already receiving an Ivermectin product monthly for the protection from heartworms. As in the equine
research, newly developed products were used to successfully eradicate the
vascular parasitic infections
in the canine test subjects. These products will also be released when
Endocrine Technologies, Inc. markets the products.
Only limited investigations as to the life cycle of the parasite
were conducted. A constant presence of vascular strongyle type parasites was noted in
equine test subjects, even with negative fecal analysis. This supports the findings
of constant re-infection from reproduction and not just gastrointestinal
migration. Vast amounts of research
exists to support the level of systemic damage done by an infection of this
type, so no more was performed. More value was placed on the investigation
to determine the frequency of parasite positive samples.
This research project is not an attempt to challenge the veracity of
existing research with
regards to equine parasites. The findings of this research suggests
that we are dealing with a mutated or different strain of strongyle type
parasite than previously
known. The findings of this research project would suggest a closer
resemblance to the Strongyloides human infection than the existing research on
equine parasites. The findings would suggest a much broader
infection level, including human, canine and equine. More research is
underway for effective control and/or eradication of these parasites.
I am grateful to the following
people who have assisted in the findings detailed in this publication: Alphabetically
- Thelma Dunnebacke, Ph.D., R. Kristapati,
Ph.D., Tej Singh, M.S., Marcia Dubois, DVM., Luann Groves, DVM., Jerry Singleton,
DVM., Barbara Truex,
DVM., Madalyn Ward, DVM., Kelsey Cook, VCA, Jennifer
Harrison, VCA, Jamie Showers, VCA.
This article has been modified for ease of understanding, the word strongyl was
used several times when discussing observed parasites. Strongyl simply
means round or compact. The usage led some readers unfamiliar with this
definition to be confused about the identification of the parasites
observed. No specific identification was performed. It has been
interesting to see that more attention was given to the potential confusion with
regards to identification, than to the overwhelming parasite infection problem,
and the ease by which it was observed in blood samples.
All data and findings are the intellectual property of
& Animal Protection Coalition, Inc.
Please note that since
publishing this article, papers have been published by UC Davis (University of
California, Davis), the CDC (Center for Disease Control), and many other
researchers in the U.S. and around the world that skeptics might want to review
before taking a position on this publication:
Cerebrospinal fluid changes in two horses with central
nervous system nematodiasis
Equine neural angiostrongylosis
ARTERY DAMAGE CAN CAUSE HIND LEG LAMENESS
In searching You Tube - this is just
one of the parasite videos found
Animal Planet's New Series
Monster's Inside Me